ZONOea (Oleoylethanolamide) is a bioactive endogenous lipid amide, shown to have beneficial effects on brain function, gut health and weight management. It has been studied for neuroprotective effects immediately after onset of cerebral ischemia. It can offer therapeutic benefits for aging, Alzheimer’s by improving lipid metabolism, increasing microglial phagocytosis. ZONOea plays crucial role in regulating food intake and energy balance, promoting satiety, meal termination, lipid metabolism through fatty acid uptake, lipolysis, and beta-oxidation. It influences dopamine, oxytocin, and histamine pathways, contributing to its effects on food intake. ZONOea regulates intestinal homeostasis (reducing intestinal permeability), microbiota composition, immune responses and metabolic functions, making it a promising therapeutic target for weight management, inflammation related gut disorders.